Every Connective Issues post starts with real evidence…not assumptions, hype, or half-truths. These are the studies and data behind the content you see on my feeds. For plain-English breakdowns and insights, follow along on social media.
KLK15 implicated in hEDS
Gensemer et al. KLK15 Alters Connective Tissues in Hypermobile Ehlers-Danlos Syndrome. iScience 2025 Preprint
2021 hEDS Review
Gensemer et al. Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes. Developmental Dynamics. 2021; 250(3): 318–344 [Link](https://doi.org/10.1002/dvdy.220
Prolotherapy in hEDS
Montana et al. Prolotherapy For the Treatment of Sacroiliac Joint Instability in Patients with Ehlers-Danlos Syndrome. Advances in Integrative Medicine 2025 Preprint
Impact of Living with EDS Study
Foster et al. The Impact of living with Ehlers-Danlos Syndrome on health-related quality of life: A systematic review following the 2017 international EDS classification. Rare 3 (2025) 100107 Link
Immune System in hEDS Study
Griggs et al. Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology. ImmunoHorizons, 2025, 9(10), vlaf044 Link
Gastroparesis Guidelines (AGA, 2025)
Staller et al. AGA Clinical Practice Guideline on Management of Gastroparesis. Gastroenterology 2025;169:828–861 Link
hEDS GWAS (Genome-Wide Association Study)
Petrucci-Nelson et al. Complex Genetics and Regulatory Drivers of Hypermobile Ehlers-Danlos Syndrome: Insights from Genome-Wide Association Study Meta-analysis. MedRxiv Pre-print (Not peer reviewed yet) Link
AGA Clinical Practice Update in EDS
Aziz et. al AGA Clinical Practice Update on GI Manifestations and Autonomic or Immune Dysfunction in Hypermobile Ehlers-Danlos Syndrome: Expert Review. Clinical Gastroenterology and Hepatology 2025;23:1291–1302 Link
Diet and Pain
Ward et al. Exploring the role of diet quality and adiposity in the pain experience: a mediation analysis. European Journal of Nutrition 2025;64,266. Link
Adipose Disorders and hEDS
Wang et al. Intersection between hypermobile Ehlers‑Danlos syndrome and adipose disorders: investigating fascial remodeling with ultrasound imaging. Journal of Rare Diseases 2025;4,52 Link
hEDS & HSD in Pediatric Cohort
Felipe et al. Unveiling the Spectrum: Clinical and Molecular Insights from a Spanish Pediatric Cohort with Hypermobility Disorders and Ehlers-Danlos Syndrome. Genes 2025, 16, 925. Link
Fibronectin Biomarker in hEDS and HSD
Ritelli et al. Bridging the Diagnostic Gap for Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Evidence of a Common Extracellular Matrix Fragmentation Pattern in Patient Plasma as a Potential Biomarker. American Journal of Medical Genetics 2025; 197:1 e63857 Link
